Peptides in Postural Orthostatic Tachycardia Syndrome
نویسنده
چکیده
Recently, increasing attention has been directed toward better understanding the physiological role and clinical importance of a wide range of endogenously released vasoactive peptides. The most well known of these are B-type natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) (1–4). However, others have also attracted attention, including C-type natriuretic peptide, vasoactive intestinal peptide, neuropeptide Y, the (uncertain in humans) Dendroaspis-type peptide, and adrenomedullin (ADM) (2–4). Although the sites of origin of these proteins differ and the triggers for their release vary, they nonetheless appear to play a role as endocrine/paracrine participants in overall cardiovascular hemodynamic control (1). Furthermore, gene expression and release of these peptides are affected by a wide range of disease states. In particular, the clinical relevance of BNP, ANP, and ADM as markers of disease severity has proved to be of special interest for prognostic assessment of patients with chronic heart failure or acute myocardial infarction (1,5–8).
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